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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleLeukotrienes play a role in the control of parasite burden in murine strongyloidiasispt_BR
dc.contributor.authorMachado, ERpt_BR
dc.contributor.authorUeta, MTpt_BR
dc.contributor.authorLourenco, EVpt_BR
dc.contributor.authorAnibal, FFpt_BR
dc.contributor.authorSorgi, CApt_BR
dc.contributor.authorSoares, EGpt_BR
dc.contributor.authorRoque-Barreira, MCpt_BR
dc.contributor.authorMedeiros, AIpt_BR
dc.contributor.authorFaccioli, LHpt_BR
unicamp.authorUniv Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Sao Paulo, Brazil Univ Estadual Campinas, Inst Biol, Dept Parasitol, Sao Paulo, Brazil Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Biol Celular Mol & Bioagentes Patogen, BR-05508 Sao Paulo, Brazil Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pathol, BR-05508 Sao Paulo, Brazilpt_BR
dc.subject.wosImmediate Hypersensitivity Reactionspt_BR
dc.subject.wosIntestinal Nematodept_BR
dc.subject.wosPolymorphonuclear Leukocytespt_BR
dc.subject.wosInflammatory Mediatorspt_BR
dc.subject.wosProtective Immunitypt_BR
dc.subject.wosRatti Infectionpt_BR
dc.description.abstractIt is clear that leukotrienes mediate inflammatory response; new aspects of leukotriene function have recently been described. In this study, we demonstrate that leukotrienes are key chemical mediators in the control of parasite burdens in mice infected with Strongyloides venezuelensis. High leukotriene levels were detected in the lungs and small intestines of Swiss mice. In infected Swiss mice treated with MK886, a leukotriene synthesis inhibitor, numbers of adult worms, and eggs/g/feces were greater than in infected-only animals. The MK886 treatment inhibited leukotriene B-4 production in the lungs and small intestines, albeit on different postinfection days. Similarly, parasite burdens and eggs/g/feces were greater in 5-lipoxygenase(-/-) mice than in wild-type animals. These observation were confirmed by histopathological study of the duodena. We subsequently observed significant lower numbers of eosinophils; and mononuclear cells in the blood, peritoneal cavity fluid, and bronchoalveolar lavage fluid of Swiss mice treated with MK886. In the lung parenchyma of infected animals, MK886 significantly inhibited synthesis of IL-5 at the beginning of infection, whereas levels of IL-12 increased progressively throughout the postinfection period. However, levels of leukotriene C-4, PGE(2), TNF-alpha, IL-3, IL-4, IFN-gamma, and IL-10 were comparable between the treated and untreated groups. Nevertheless, IgE and IgG1 (but not IgG2a) synthesis was also significantly inhibited by MK886 administration. Therefore, in S. venezuelensis-infected mice, adult worm and egg burdens are leukotriene dependent. These findings indicate potential inummostimulatory strategies involving leukotriene administration, and may serve as an alert to physicians treating Strongyloides stercoralis-infected patients presenting asthma-like symptoms because use of 5-lipoxygenase inhibitors may worsen the
dc.relation.ispartofJournal Of Immunologypt_BR
dc.relation.ispartofabbreviationJ. Immunol.pt_BR
dc.publisherAmer Assoc Immunologistspt_BR 15pt_BR
dc.identifier.citationJournal Of Immunology. Amer Assoc Immunologists, v. 175, n. 6, n. 3892, n. 3899, 2005.pt_BR
dc.sourceWeb of Sciencept_BR
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