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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleRED-CELL MEMBRANE-PROTEIN ABNORMALITIES IN HEREDITARY SPHEROCYTOSIS IN BRAZILpt_BR
dc.contributor.authorSAAD, STOpt_BR
dc.contributor.authorCOSTA, FFpt_BR
dc.contributor.authorVICENTIM, DLpt_BR
dc.contributor.authorSALLES, TSIpt_BR
dc.contributor.authorPRANKE, PHLpt_BR
unicamp.authorUNIV ESTADUAL CAMPINAS,HAEMOCTR,CAMPINAS,SP,BRAZILpt_BR
dc.subjectHEREDITARY SPHEROCYTOSISpt_BR
dc.subjectSPECTRINpt_BR
dc.subjectANKYRINpt_BR
dc.subjectBAND 3pt_BR
dc.subjectANEMIApt_BR
dc.subject.wosErythrocyte Membranept_BR
dc.subject.wosSpectrinpt_BR
dc.subject.wosAnkyrinpt_BR
dc.subject.wosDeficiencypt_BR
dc.subject.wosSkeletonpt_BR
dc.subject.wosGenept_BR
dc.description.abstractWe studied 14 kindred and nine unrelated patients from southeastern Brazil with the typical form of hereditary spherocytosis. Diagnosis was made on the basis of clinical features, presence of spherocytes on the peripheral blood smears and an abnormal osmotic fragility test. By densitometric tracing of SDS-PAGE stained by Coomassie blue, we detected isolated deficiency of spectrin in 39% of our patients, combined spectrin and ankyrin deficiency in 13%, and deficiency of band 3 in 13%. One of our patients presented ankyrin deficiency without spectrin reduction. Our data suggest that, despite ethnic differences among the Brazilian and European or North-American populations, these biochemical abnormalities in HS patients may be similar.pt
dc.relation.ispartofBritish Journal Of Haematologypt_BR
dc.relation.ispartofabbreviationBr. J. Haematol.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherBlackwell Science Ltdpt_BR
dc.date.issued1994pt_BR
dc.date.monthofcirculationOCTpt_BR
dc.identifier.citationBritish Journal Of Haematology. Blackwell Science Ltd, v. 88, n. 2, n. 295, n. 299, 1994.pt_BR
dc.language.isoenpt_BR
dc.description.volume88pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage295pt_BR
dc.description.lastpage299pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0007-1048pt_BR
dc.identifier.wosidWOS:A1994PL81200011pt_BR
dc.identifier.doi10.1111/j.1365-2141.1994.tb05021.xpt_BR
dc.date.available2014-08-01T18:33:34Z
dc.date.available2015-11-26T17:05:49Z-
dc.date.accessioned2014-08-01T18:33:34Z
dc.date.accessioned2015-11-26T17:05:49Z-
dc.description.provenanceMade available in DSpace on 2014-08-01T18:33:34Z (GMT). No. of bitstreams: 0 Previous issue date: 1994en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:05:49Z (GMT). No. of bitstreams: 0 Previous issue date: 1994en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80793
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/80793-
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