Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/80651
Type: Artigo de periódico
Title: Inhibition of tonic spinal glutamatergic activity induces antinociception in the rat
Author: Tambeli, CH
Parada, CA
Levine, JD
Gear, RW
Abstract: Inhibition of tonic activity in spino-supraspinal projection neurons induces heterosegmental antinociception that is mediated by opioid receptors in nucleus accumbens. To investigate the origin of this tonic activity, we evaluated the ability of inhibiting neurotransmission in the spinal cord to produce heterosegmental antinociception in the trigeminal nociceptive jaw-opening reflex (JOR) in the rat. Spinal intrathecal administration of calcium channel blockers attenuated the JOR, suggesting that the tonic spinal activity depends on synaptic input. To identify the excitatory neurotransmitter receptors involved, selective antagonists for AMPA/kainate, mGluR(1), NMDA or NK1 receptors were administered intrathecally to the spinal cord. The AMPA/kainate and mGluR(1) receptor antagonists, but not the NMDA or NK1 receptor antagonists, induced antinociception, which was antagonized by intra-accumbens administration of the selective mu-opioid receptor antagonist CTOP. Thus, inhibition of tonic spinal glutamatergic activity resulted in supraspinally mediated antinociception. As this antinociception occurred in the absence of interventions that would produce a facilitated nociceptive state, this tonic glutamatergic activity is important in setting nociceptive threshold.
Subject: antinociception
AMPA
kainate
NK1
mGluR1
NMDA
excitatory
nucleus accumbens
glutamate
Country: Inglaterra
Editor: Blackwell Publishing Ltd
Rights: fechado
Identifier DOI: 10.1046/j.1460-9568.2002.02204.x
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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