Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/80643
Type: Artigo de periódico
Title: Recognizing alpha-, beta- or gamma-substitution in pyridines by mass spectrometry
Author: Corilo, YE
Eberlin, MN
Abstract: A general mass spectrometric method able to recognize the site of substitution of monosubstituted pyridines is described. The method requires that the molecule under investigation forms, upon ionization and dissociation, the respective alpha-, beta- or gamma-pyridinium ion of m/z 78. Pyridinium ions are stable and common fragments of ionized and protonated pyridines and are found to function as appropriate structurally diagnostic fragment ions. They can be identified by their characteristic and nearly identical collision-induced dissociation behavior and distinguished by the combined use of two structurally diagnostic ion/molecule reactions with acetonitrile and 2-methyl-1,3-dioxolane. alpha-, beta- or gamma-substitution in pyridines can, therefore, be securely recognized via an MS-only method based on structurally diagnostic ions and by the inspection of a single molecule (no need for intracomparisons within the whole set of isomers). Copyright (C) 2008 John Wiley & Sons, Ltd.
Subject: ion/molecule reactions
isomer distinction
pyridines
pentaquadrupole mass spectrometry
structurally diagnostic ions
Country: EUA
Editor: Wiley-blackwell
Rights: fechado
Identifier DOI: 10.1002/jms.1442
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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