Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/80576
Type: Artigo de periódico
Title: INHIBITION OF DNA-POLYMERASE ALPHA AND REVERSE-TRANSCRIPTASE ACTIVITIES BY HPA-23
Author: AOYAMA, H
JUCA, MB
ZOURGUI, L
LITVAK, S
Abstract: We describe the effect of HPA-23 in the DNA synthesis reaction catalyzed by DNA polymerase-alpha and reverse transcriptase. 0.085 and 0.017-mu-M of HPA-23 inhibited 50% of DNA polymerase alpha-activity in the presence of activated DNA and poly(dA)-oligo(dT), respectively. However, for reverse transcriptase, this same effect was observed only with 6.76-mu-M of the drug independently of the template-primer used (activated DNA or poly (rA)-oligo(dT)). HPA-23 was a non-competitive inhibitor with respect to activated DNA and to TTP in the DNA polymerase alpha-reaction.
Subject: DNA POLYMERASE
REVERSE TRANSCRIPTASE
HPA-23
INHIBITION
Country: Brasil
Editor: Inst Tecnologia Parana
Rights: aberto
Date Issue: 1991
Appears in Collections:Unicamp - Artigos e Outros Documentos

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