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Type: Artigo de periódico
Title: Inhibition of calcification of bovine pericardium after treatment with biopolymers, E-beam irradiation and in vitro endothelization
Author: Polak, R
Rodas, ACD
Chicoma, DL
Giudici, R
Beppu, MM
Higa, OZ
Pitombo, RNM
Abstract: This work has investigated the in vitro calcification of bovine pericardium (BP) treated with chitosan (C), silk fibroin (SF) and electron beam irradiation after its endothelization in vitro. For this purpose, freeze-dried BP membranes treated with mixtures of C and SF (1:3, 1:1 and 3:1) and then irradiated by electron beam irradiation were seeded with human umbilical vein endothelial cells (HUVEC) in vitro. After 3 weeks of cultivation these membranes were submitted to in vitro calcification tests using simulated body fluid as the calcifying agent. Control membranes were also studied (without endothelial cells exposure). The results have shown that the membrane compatibility with HUVECs in vitro prevent such biomaterial from calcifying, showing a potential application in biomaterial area, such as cardiac valves and repair patches. (c) 2012 Elsevier B.V. All rights reserved.
Subject: Bovine pericardium
Electron beam irradiation
Endothelial cell
Silk fibroin
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/j.msec.2012.08.009
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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