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|Type:||Artigo de periódico|
|Title:||Inhibition of avian myeloblastosis virus reverse transcriptase by an alkaloid purified from Peschiera campestris|
|Abstract:||12-methoxy-Nb-methylvoachalotine, an alkaloid purified from Peschiera campestris inhibited avian myeloblastosis virus reverse transcriptase activities. This inhibition was dependent on the template-primer used; in comparison with polyriboadenylic acid, the polyribocytidylic acid-directed reaction was more affected by the alkaloid. A similar inhibition by the alkaloid was observed both in the presence of polyriboadenylic acid or its 2'-fluorinated analogue. This inhibition also occurred in the presence of Mn2+ instead of Mg2+ as the divalent cation. Classical non-competitive inhibition kinetics were obtained with respect to activated DNA and to polyriboadenylic acid.|
|Editor:||John Wiley & Sons Ltd|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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