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Type: Artigo de periódico
Title: Inhibition of avian myeloblastosis virus reverse transcriptase by an alkaloid purified from Peschiera campestris
Author: Juca, MB
Aoyama, H
Abstract: 12-methoxy-Nb-methylvoachalotine, an alkaloid purified from Peschiera campestris inhibited avian myeloblastosis virus reverse transcriptase activities. This inhibition was dependent on the template-primer used; in comparison with polyriboadenylic acid, the polyribocytidylic acid-directed reaction was more affected by the alkaloid. A similar inhibition by the alkaloid was observed both in the presence of polyriboadenylic acid or its 2'-fluorinated analogue. This inhibition also occurred in the presence of Mn2+ instead of Mg2+ as the divalent cation. Classical non-competitive inhibition kinetics were obtained with respect to activated DNA and to polyriboadenylic acid.
Subject: reverse transcriptase
Country: Inglaterra
Editor: John Wiley & Sons Ltd
Rights: fechado
Date Issue: 1996
Appears in Collections:Unicamp - Artigos e Outros Documentos

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