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Type: Artigo de periódico
Title: Inherited pericentric inversion of chromosome 16 in chronic phase of chronic myeloid leukaemia
Author: Silva, PMR
Lourenco, GJ
Bognone, RAV
Delamain, MT
Pinto-Junior, W
Lima, CSP
Abstract: The simultaneous occurrence of two specific acquired chromosomal abnormalities in chronic or acute leukaemias is rare. Inherited chromosomal abnormalities are also rare events in the general population. In chronic myeloid leukaemia (CML), characterised by the t(9;22)(q34;q11), the inv(16)(p13q22) has been described associated with the acceleration of disease or onset of blast crisis. We report on a patient with chronic phase of CML and both acquired t(9;22)(q34;q11) and inherited inv(16)(p13q22), who obtained a complete remission of the disease after bone marrow transplant. Therefore, it is worth to comment that an additional chromosomal abnormality in disease does not obligatory mean transformation of the disease to a more aggressive form, since chromosomal abnormalities are also seen in normal individuals. (c) 2005 Elsevier Ltd. All rights reserved.
Subject: chronic myeloid leukaemia
acquired chromosomal abnormality
inherited chromosomal abnormality
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/j.leukres.2005.06.003
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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