Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/80459
Type: Artigo de periódico
Title: INFLUENCE OF THE RAPID ACETYLATOR PHENOTYPE ON THE EMERGENCE OF DDS RESISTANT MYCOBACTERIUM-LEPRAE
Author: COSTA, HC
OPROMOLLA, DVA
VIRMOND, M
BEIGUELMAN, B
Abstract: Twenty one lepromatous cases with suspected diaminodiphenyl sulfone (DDS) resistance had their isoniazid acetylator phenotype determined. The resistance of Mycobacterium leprae to this sulfone was investigated by means of foot pad tests in BALB/c mice. Results indicate that the emergence of complete resistance to DDS in M. leprae is more probable in rapid than in slow acetylators. It appears that rapid acetylators require higher doses of DDS than slow acetylators since the bacillary concentration in the lesions of the patients with DDS sensitive M. leprae was more than 17 times higher among rapid than among slow acetylators.
Country: Brasil
Editor: Soc Brasil Genetica
Rights: aberto
Date Issue: 1993
Appears in Collections:Unicamp - Artigos e Outros Documentos

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