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|Type:||Artigo de periódico|
|Title:||Influence of the glutathione s-transferase gene polymorphisms on the susceptibility to basal cell skin carcinoma|
|Abstract:||Background: The identification of groups at high risk in fundamental to determine preventive strategies for skin cancer. Destructive reactive oxygen species produced by UVA or chemical carcinogens are metabolized by a series of enzymes. Polymorphisms of genes encoding for these enzymes may produce defective proteins with a diminished ability to detoxify a wide range of carcinogens. Aims: To ascertain the influence and potential interactions of several polymorphisms of genes encoding four important antioxidant GST enzymes in the susceptibility to cancer among Brazilians. Material and methods: We compared the genotypes of Glutathione S-Transferase mu, theta, pi and omega (GSTM1, GSTT1, GSTP1 and GSTO2) in a group of 102 patients with skin lesions and 124 controls. Results: Patients with Basal Cell Skin Carcinoma (BCC) presented the combined GSTM1-GSTT1+ genotype more frequently (49.1%) than controls. Results: Patients with Basal Cell Skin Carcinoma (BCC) presented the combined GSTM1-GSTT1+ genotype more frequently (49.1%) than controls (20.8%) (Fisher test, p = 0.04), conferring a 2.273 (Odds Ratio; 95% CI = 1.199-4.308) higher risk for BCC. We were not able to find any other association between genotypes or between any genotype and the patients' clinical features. Conclusions: The GST profile may help identify Brazilian individuals at higher risk for BCC.|
|Subject:||carcinoma, basal cell|
|Editor:||Soc Medica Santiago|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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