Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/80410
Type: Artigo de periódico
Title: Regression of gastroesophageal reflux disease symptoms using dietary supplementation with melatonin, vitamins and aminoacids: comparison with omeprazole
Author: Pereira, RD
Abstract: The prevalence of gastroesophageal reflux disease ( GERD) is increasing. GERD is a chronic disease and its treatment is problematic. It may present with various symptoms including heartburn, regurgitation, dysphagia, coughing, hoarseness or chest pain. The aim of this study was to investigate if a dietary supplementation containing: melatonin, L-tryptophan, vitamin B6, folic acid, vitamin B12, methionine and betaine would help patients with GERD, and to compare the preparation with 20 mg omeprazole. Melatonin has known inhibitory activities on gastric acid secretion and nitric oxide biosynthesis. Nitric oxide has an important role in the transient lower esophageal sphincter relaxation ( TLESR), which is a major mechanism of reflux in patients with GERD. Others biocompounds of the formula display anti-inflammatory and analgesic effects. A single blind randomized study was performed in which 176 patients underwent treatment using the supplement cited above ( group A) and 175 received treatment of 20 mg omeprazole ( group B). Symptoms were recorded in a diary and changes in severity of symptoms noted. All patients of the group A ( 100%) reported a complete regression of symptoms after 40 days of treatment. On the other hand, 115 subjects ( 65.7%) of the omeprazole reported regression of symptoms in the same period. There was statiscally significant difference between the groups ( P < 0.05). This formulation promotes regression of GERD symptoms with no significant side effects.
Subject: betaine
esophagitis
folate
gastroesophageal reflux disease
l-tryptophan
melatonin
methionine
omeprazole
S-adenosyl-l-methionine
vitamin B12
vitamin B6
Country: Inglaterra
Editor: Blackwell Publishing
Rights: fechado
Identifier DOI: 10.1111/j.1600-079X.2006.00359.x
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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