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|Type:||Artigo de periódico|
|Title:||Regioselectivity in aromatic Claisen rearrangements|
|Abstract:||Theoretical calculations and the isomeric product composition for a series of eight meta-substituted allyl aryl ethers confirm the reliability of a new H-1 NMR methodology used to predict aromatic Claisen regioselectivity from ground-state conformational preference of the reactant allyloxy group. Frontier HOMO-LUMO intramolecular orbital interactions, a classical approach in predicting reactivity and selectivity for Claisen rearrangements of allyl vinyl ethers, is shown to fail to mimic transition-state orbital interactions for aromatic Claisen rearrangements of meta-substituted allyl aryl ethers. B3LYP/6-31G(d,p) calculations on reactants and transition states are shown, however, to correctly predict the outcome of such aromatic Claisen rearrangements from either the preferential reactant ground-state conformation (theoretical predictions that agree with the NMR measurements) or the less energetic transition state, or both.|
|Editor:||Amer Chemical Soc|
|Citation:||Journal Of Organic Chemistry. Amer Chemical Soc, v. 68, n. 14, n. 5493, n. 5499, 2003.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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