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Type: Artigo de periódico
Title: Regio- and stereoselective Heck arylations of N-carbomethoxy-L-3-dehydroproline methyl ester with arenediazonium salts. Total synthesis of neuroexcitatory aryl kainoids
Author: da Silva, KP
Godoi, MN
Correia, CRD
Abstract: The Heck arylation of N-carbomethoxy-(L)-3-dehydroproline methyl ester with arenediazonium tetrafluoroborates produced chiral 4-aryldehydroproline derivatives in moderate to good yields in a highly regio- and stereocontrolled fashion. A rationale for the unexpected high regioselectivity is provided using Deeth's model. Heck adduct 15 (G = o-CH3O) was converted into several aryl kainoids using concise and efficient routes.
Country: EUA
Editor: Amer Chemical Soc
Citation: Organic Letters. Amer Chemical Soc, v. 9, n. 15, n. 2815, n. 2818, 2007.
Rights: fechado
Identifier DOI: 10.1021/ol070980t
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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