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|Type:||Artigo de periódico|
|Title:||Regio- and enantio selective reduction of methyleneketoesters mediated by Saccharomyces cerevisiae|
|Abstract:||Methyleneketoesters were readily prepared in high yields by performing a direct alpha-methylenation of the corresponding ketoesters using a previously described protocol. Reactions of ethyl 2-methylene-3-oxo-3-arylpropanoates 2a-c catalyzed by S. cerevisiae were performed with good conversions to give reductions of the C=C, C=O or both, depending on the reaction conditions and on the substitution of the aryl moiety. Reaction 14 of 3-methylene-2-oxo-4-phenylbutyrate 2d was carried out with free yeast cells and with yeast cells immobilized with calcium alginate, in which the major products resulted from C=C and C=O bond reduction. [GRAPHICS] (c) 2007 Elsevier B.V. All rights reserved.|
|Editor:||Elsevier Science Bv|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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