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Type: Artigo de periódico
Title: Regio- and enantio selective reduction of methyleneketoesters mediated by Saccharomyces cerevisiae
Author: Clososki, GC
Milagre, CDF
Moran, PJS
Rodrigues, JAR
Abstract: Methyleneketoesters were readily prepared in high yields by performing a direct alpha-methylenation of the corresponding ketoesters using a previously described protocol. Reactions of ethyl 2-methylene-3-oxo-3-arylpropanoates 2a-c catalyzed by S. cerevisiae were performed with good conversions to give reductions of the C=C, C=O or both, depending on the reaction conditions and on the substitution of the aryl moiety. Reaction 14 of 3-methylene-2-oxo-4-phenylbutyrate 2d was carried out with free yeast cells and with yeast cells immobilized with calcium alginate, in which the major products resulted from C=C and C=O bond reduction. [GRAPHICS] (c) 2007 Elsevier B.V. All rights reserved.
Country: Holanda
Editor: Elsevier Science Bv
Citation: Journal Of Molecular Catalysis B-enzymatic. Elsevier Science Bv, v. 48, n. 41732, n. 70, n. 76, 2007.
Rights: fechado
Identifier DOI: 10.1016/j.molcatb.2007.06.005
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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