Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/80369
Type: Artigo de periódico
Title: INFLUENCE OF SUBACUTE STARVATION ON CARDIAC RESPONSE TO ISOPROTERENOL IN RATS
Author: BASILE, A
CAMPOS, ACL
ESTEVES, SC
BORDIN, S
MANTOVANI, M
Abstract: Several studies have reported that the heart is severely affected by chronic malnutrition. However, the influence of these alterations on cardiac function remains unclear. The aim of this study was to evaluate the effects of subacute starvation on the heart chronotropic response to a beta-adrenergic agonist (isoproterenol). Twelve rats were fed rat chow ad libitum or a 50%-restricted diet for 17 days. The rats were killed, the right atrium was isolated and incubated, and in vitro spontaneous cardiac contractions and frequency were registered. Cumulative doses of isoproterenol were added to the solution until maximal cardiac frequency was achieved. A deficit of 25% in the weight gain was observed in study rats compared with controls (92.6 +/- 10.2 vs. 113.8 +/- 19.2 g,p < 0.05). Mean daily food intake was 4.8 +/- 0.1 and 9.8 +/- 0.5 g/day for semistarved and control rats, respectively. The in vitro cardiac frequency of the semistarved rats was similar to that of controls (290 +/- 15 and 305 +/- 23 beats/min, respectively, NS). However, when isoproterenol was added to the solution, maximal cardiac frequency of the semistarved rats (435 +/- 51 beats/min) was lower than that of control rats (508 +/- 34 beats/min, p < 0.005). These findings suggest that subacute starvation may alter the cardiac response to beta-adrenergic agonists.
Subject: CARDIAC FUNCTION
STARVATION
ISOPROTERENOL
Editor: Elsevier Science Inc
Rights: fechado
Date Issue: 1991
Appears in Collections:Unicamp - Artigos e Outros Documentos

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