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Type: Artigo de periódico
Title: Influence of stimulus frequency on blockade induced by pancuronium and rocuronium. Study on rats phrenic nerve-diaphragm preparation
Author: Braga, ADD
Munoz, DC
Braga, FSD
de Araujo, DR
Poterio, MB
Mantovani, M
Abstract: Purpose: To evaluate the influence of two stimulation frequencies on the installation of neuromuscular blockade produced by pancuronium and rocuronium on the rat diaphragm. Methods: Diaphragms were submitted to an indirect frequency stimulation of 0.1 and 1 Hz (Groups I and II, respectively). Subgroups were formed (n=5) according to the neuromuscular blocker employed (pancuronium-2 mu g/ml and rocuronium-4 mu g/ml). The twitch height depression was evaluated at 5, 15 and 30 minutes after adding the neuromuscular blocker. Results: The decrease in twitch height was greater (p<0.01) with a frequency of I Hz at all time periods studied both in preparations that are blocked with pancuronium and in those that are blocked with rocuronium. Conclusion: The frequency of stimulation interferes significantly with the installation of neuromuscular blockade produced by pancuronium and rocuronium, since the reduction in amplitude of the rat diaphragm response was greater for I Hz frequencies, at all periods studied.
Subject: neuromuscular nondepolarizing agents
neuromuscular blocking agents
phrenic nerve
electric stimulation
Country: Brasil
Editor: Acta Cirurgica Brasileira
Citation: Acta Cirurgica Brasileira. Acta Cirurgica Brasileira, v. 22, n. 6, n. 446, n. 450, 2007.
Rights: aberto
Identifier DOI: 10.1590/S0102-86502007000600006
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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