Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/80336
Type: Artigo de periódico
Title: Reduction of Inducible Nitric Oxide Synthase via Angiotensin Receptor Blocker Prevents the Oxidative Retinal Damage in Diabetic Hypertensive Rats
Author: Silva, KC
Rosales, MAB
de Faria, JBL
de Faria, JML
Abstract: Purpose: To investigate if nitric oxide (NO) system contributes to the beneficial effect of angiotensin II type 1 receptor (AT 1) blocker losartan in the retina of diabetic spontaneously hypertensive rats (SHR). Methods: Diabetic SHR were randomized to receive oral treatment with losartan (DM-SHRLos). After 20 days, the rats were euthanized and the retinas collected. Results: Diabetic SHR rats exhibited a significant increase in glial fibrillary acidic protein (GFAP) and decrease in occludin, markers of early diabetic retinopathy (DR). The oxidative status, evaluated by NO end-products (NO(x)(-)) levels along with the antioxidative system superoxide dismutase, revealed an accentuated imbalance in favor to oxidants in DM-SHR leading to a higher tyrosine nitration and DNA damage. The inducible NO synthase (iNOS) was also elevated in DM-SHR rats. The treatment with losartan ameliorated all of the above alterations. Conclusions: Oral treatment with losartan reduces iNOS expression and reestablishes the redox status, thus ameliorating the early markers of DR in a model of diabetes and hypertension.
Subject: Angiotension II type 1 receptor blocker
Diabetic retinopathy
Inducible nitric oxide synthase
Nitric oxide end products
Oxidative stress
Country: EUA
Editor: Taylor & Francis Inc
Rights: fechado
Identifier DOI: 10.3109/02713681003664923
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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