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Type: Artigo de periódico
Title: Reduced renal sodium excretion in primary hypertensive patients after an oral glucose load
Author: Gontijo, JAR
Muscelli, EOA
Abstract: This study was designed to determine urinary sodium excretion in response to an oral glucose load in hypertensive patients. Fifteen hypertensive patients and eighteen normotensive subjects were studied after an overnight fast and for 4 h after the ingestion of 100 g glucose. A subgroup of untreated, nonobese, primary hypertensive patients (five of the 15 hypertensive patients) became hyperinsulinemic (total area under the insulin curve [TAUC]: 33,080 +/- 3348 mu U ml(-1) 120 min(-1)) in response to an oral glucose load compared to normotensive subjects (TAUC: 3670<13.731<23,693 mu U ml(-1) 120 min(-1)) or to the other subgroup of normoinsulinemic hypertensive individuals (TAUC: 10,221 +/- 1615 mu U ml(-1) 120 min(-1)) despite a similar serum glucose concentration in both groups. A significant decrease in renal sodium excretion in the entire hypertensive group (47.1 +/- 4.7%, P<0.019) compared to the normotensive (20.0 +/- 10.5%) subjects was also observed during the oral glucose tolerance test. Decreased renal sodium excretion was followed by a transient increase in urinary acid excretion. We speculate that the increase in insulin secretion may be responsible for the sodium-dependent increase in intracellular Ca2+, cellular H+ output and blood pressure in a subgroup of salt-sensitive patients with hypertension. New studies should be designed to identify the precise mechanisms involved in the interaction between hypertension, serum insulin-glucose levels and the magnitude of the renal tubule reabsorption abnormality.
Subject: primary hypertension
glucose intolerance
renal function
sodium excretion
Country: Brasil
Editor: Assoc Bras Divulg Cientifica
Citation: Brazilian Journal Of Medical And Biological Research. Assoc Bras Divulg Cientifica, v. 29, n. 10, n. 1291, n. 1299, 1996.
Rights: aberto
Date Issue: 1996
Appears in Collections:Unicamp - Artigos e Outros Documentos

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