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Type: Artigo de periódico
Title: Influence of probe pressure on the diffuse correlation spectroscopy blood flow signal: extra-cerebral contributions
Author: Mesquita, RC
Schenkel, SS
Minkoff, DL
Lu, XP
Favilla, CG
Vora, PM
Busch, DR
Chandra, M
Greenberg, JH
Detre, JA
Yodh, AG
Abstract: A pilot study explores relative contributions of extra-cerebral (scalp/skull) versus brain (cerebral) tissues to the blood flow index determined by diffuse correlation spectroscopy (DCS). Microvascular DCS flow measurements were made on the head during baseline and breath-holding/hyperventilation tasks, both with and without pressure. Baseline (resting) data enabled estimation of extra-cerebral flow signals and their pressure dependencies. A simple two-component model was used to derive baseline and activated cerebral blood flow (CBF) signals, and the DCS flow indices were also cross-correlated with concurrent Transcranial Doppler Ultrasound (TCD) blood velocity measurements. The study suggests new pressure-dependent experimental paradigms for elucidation of blood flow contributions from extra-cerebral and cerebral tissues. (C) 2013 Optical Society of America
Country: EUA
Editor: Optical Soc Amer
Citation: Biomedical Optics Express. Optical Soc Amer, v. 4, n. 7, n. 978, n. 994, 2013.
Rights: aberto
Identifier DOI: 10.1364/BOE.4.000978
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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