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Type: Artigo de periódico
Title: Influence of liposomal local anesthetics on platelet aggregation in vitro
Author: Pinto, LMA
Pereira, R
de Paula, E
de Nucci, G
Santana, MHA
Donato, JL
Abstract: We assessed the effect of local anesthetics (LA) from different families such as esters (benzocaine), linear aminoamides (lidocaine) and cyclic aminoamides (bupivacaine) on the platelet aggregation induced by ADP. Liposomal formulations of the three LA, prepared with egg phosphatidylcholine: cholesterol a-tocopherol, were also tested. The three LA were able to inhibit platelet aggregation induced by ADP, in the following order: bupivacaine > lidocaine > benzocaine. After encapsulation into liposomes the inhibitory effect increased for all anesthetics studied, showing that aggregation tests could be used to assess the toxicity of new drug formulations.
Subject: liposomes
local anesthetics
platelet aggregation
Country: EUA
Editor: Marcel Dekker Inc
Citation: Journal Of Liposome Research. Marcel Dekker Inc, v. 14, n. 41671, n. 51, n. 59, 2004.
Rights: fechado
Identifier DOI: 10.1081/LPR-120039697
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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