Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/801
Type: Artigo de periódico
Title: Exposure to lead exacerbates dental fluorosis
Author: LEITE, G. A. S.
SAWAN, R. M. M.
TEOFILO, J. M.
PORTO, I. M.
SOUSA, F. B.
GERLACH, R. F.
Abstract: Aim: Our aim was to test: the hypothesis that co-exposure to lead and fluoride alter the severity of enamel fluorosis. Materials and methods: Wistar rats were allocated in four groups: control, and 3 groups that received water containing 100 ppm of fluoride (F), 30 ppm of lead (Pb), or 100 ppm of F and 30 ppm of Pb (F + Pb) from the beginning of gestation. Enamel analysis and F and Pb determinations in enamel, dentine, and bone were performed in 81-day-old animals. Fluorosis was quantified using a new fluorosis index based on the identification of incisor enamel defects (white bands and white islets, representing hypomineralization, and cavities) weighted according to their severity and quantity. Hypomineralization was validated histopathologically by polarizing microscopy and microradiography. Scores were given by two blinded calibrated examiners (intra and interexaminer kappa values were 0.8 and 0.86, respectively). Results: The control and the Pb groups presented normal enamel. The F + Pb group presented more severe enamel defects compared with the F group (P < 0.0001). Conclusions: This study shows that lead exacerbates dental fluorosis in rodents, suggesting that co-exposure to lead may affect the degree of fluorosis. (C) 2011 Elsevier Ltd. All rights reserved.
Subject: Fluoride
Lead
Fluorosis
Rat incisor
Environmental toxicology
Country: Inglaterra
Editor: PERGAMON-ELSEVIER SCIENCE LTD
Rights: fechado
Identifier DOI: 10.1016/j.archoralbio.2010.12.011
Address: http://dx.doi.org/10.1016/j.archoralbio.2010.12.011
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Date Issue: 2011
Appears in Collections:FOP - Artigos e Outros Documentos

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