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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleRegulation of insulin-stimulated tyrosine phosphorylation of Shc and Shc/Grb2 association in liver, muscle, and adipose tissue of epinephrine- and streptozotocin-treated ratspt_BR
dc.contributor.authorPaez-Espinosa, Vpt_BR
dc.contributor.authorRocha, EMpt_BR
dc.contributor.authorVelloso, LApt_BR
dc.contributor.authorSaad, MJApt_BR
unicamp.authorUniv Estadual Campinas, UNICAMP, Fac Ciencias Med, Dept Clin Med, BR-13081970 Campinas, SP, Brazil Univ Estadual Campinas, UNICAMP, Inst Biol, Dept Fisiol & Biofis, BR-13081970 Campinas, SP, Brazilpt_BR
dc.subjectepinephrinept_BR
dc.subjectdiabetes mellituspt_BR
dc.subjectstreptozotocinpt_BR
dc.subjectinsulin receptor substrate-1pt_BR
dc.subjectShcpt_BR
dc.subjectShc-Grb2 associationpt_BR
dc.subject.wosMitogenic Signal-transductionpt_BR
dc.subject.wosReceptor Substrate Familypt_BR
dc.subject.wosActivated Protein-kinasept_BR
dc.subject.wosPhosphatidylinositol 3-kinasept_BR
dc.subject.wosPhosphotyrosine Proteinpt_BR
dc.subject.wosGrowth-hormonept_BR
dc.subject.wosDiabetic Ratspt_BR
dc.subject.wosDomainpt_BR
dc.subject.wosIrs-1pt_BR
dc.subject.wosCellspt_BR
dc.description.abstractShc protein phosphorylation has been extensively characterized as the initial step that activates a complex mitogenic pathway through its association with Grh2. In the present study, we investigated the adrenergic control of insulin-induced She phosphorylation and Shc-Grb2 association, and the modulating effect of streptozotocin-induced diabetes mellitus on She phosphorylation and Shc/Grb2 association. Acute treatment with epinephrine, which leads to a normoglycemic insulin-resistant state, does not affect insulin-induced She tyrosine phosphorylation or Shc-Grb2 association in liver, muscle, or fat. By contrast, a significant increase in insulin-induced She phosphorylation is observed in liver and muscle of rats treated with streptozotocin. The association of Shc/Grb2 is also increased in both tissues following insulin treatment, These data suggest that while epinephrine preserves the insulin/induced phosphorylation of She and the mitogenic pathway stimulated by Shc-Grb2 association, treatment with streptozotocin leads to a tissue-specific increase in the activity of the initial step that ultimately results in the activation of the Shc/Grb2 mitogenic pathway.pt
dc.relation.ispartofEndocrinept_BR
dc.relation.ispartofabbreviationEndocrinept_BR
dc.publisher.cityTotowapt_BR
dc.publisher.countryEUApt_BR
dc.publisherHumana Press Incpt_BR
dc.date.issued2001pt_BR
dc.date.monthofcirculationAPRpt_BR
dc.identifier.citationEndocrine. Humana Press Inc, v. 14, n. 3, n. 295, n. 302, 2001.pt_BR
dc.language.isoenpt_BR
dc.description.volume14pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage295pt_BR
dc.description.lastpage302pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0969-711Xpt_BR
dc.identifier.wosidWOS:000169301400003pt_BR
dc.identifier.doi10.1385/ENDO:14:3:295pt_BR
dc.date.available2014-11-15T12:39:28Z
dc.date.available2015-11-26T16:11:14Z-
dc.date.accessioned2014-11-15T12:39:28Z
dc.date.accessioned2015-11-26T16:11:14Z-
dc.description.provenanceMade available in DSpace on 2014-11-15T12:39:28Z (GMT). No. of bitstreams: 1 WOS000169301400003.pdf: 351901 bytes, checksum: 59eb75079b2f7a87551fcfa77d90dff8 (MD5) Previous issue date: 2001en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:11:14Z (GMT). No. of bitstreams: 2 WOS000169301400003.pdf: 351901 bytes, checksum: 59eb75079b2f7a87551fcfa77d90dff8 (MD5) WOS000169301400003.pdf.txt: 32466 bytes, checksum: b7abba85c053722797c37a183958d7eb (MD5) Previous issue date: 2001en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80058pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/80058
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/80058-
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