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Type: Artigo de periódico
Title: Regulation of insulin-stimulated tyrosine phosphorylation of Shc and Shc/Grb2 association in liver, muscle, and adipose tissue of epinephrine- and streptozotocin-treated rats
Author: Paez-Espinosa, V
Rocha, EM
Velloso, LA
Saad, MJA
Abstract: Shc protein phosphorylation has been extensively characterized as the initial step that activates a complex mitogenic pathway through its association with Grh2. In the present study, we investigated the adrenergic control of insulin-induced She phosphorylation and Shc-Grb2 association, and the modulating effect of streptozotocin-induced diabetes mellitus on She phosphorylation and Shc/Grb2 association. Acute treatment with epinephrine, which leads to a normoglycemic insulin-resistant state, does not affect insulin-induced She tyrosine phosphorylation or Shc-Grb2 association in liver, muscle, or fat. By contrast, a significant increase in insulin-induced She phosphorylation is observed in liver and muscle of rats treated with streptozotocin. The association of Shc/Grb2 is also increased in both tissues following insulin treatment, These data suggest that while epinephrine preserves the insulin/induced phosphorylation of She and the mitogenic pathway stimulated by Shc-Grb2 association, treatment with streptozotocin leads to a tissue-specific increase in the activity of the initial step that ultimately results in the activation of the Shc/Grb2 mitogenic pathway.
Subject: epinephrine
diabetes mellitus
insulin receptor substrate-1
Shc-Grb2 association
Country: EUA
Editor: Humana Press Inc
Citation: Endocrine. Humana Press Inc, v. 14, n. 3, n. 295, n. 302, 2001.
Rights: fechado
Identifier DOI: 10.1385/ENDO:14:3:295
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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