Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Efficacy of the HPV-16/18 AS04-Adjuvanted Vaccine Against Low-Risk HPV Types (PATRICIA Randomized Trial): An Unexpected Observation
Author: Szarewski, A
Skinner, SR
Garland, SM
Romanowski, B
Schwarz, TF
Apter, D
Chow, SN
Paavonen, J
Del Rosario-Raymundo, MR
Teixeira, JC
De Carvalho, NS
Castro-Sanchez, M
Castellsague, X
Poppe, WAJ
De Sutter, P
Huh, W
Chatterjee, A
Tjalma, WA
Ackerman, RT
Martens, M
Papp, KA
Bajo-Arenas, J
Harper, DM
Torne, A
David, MP
Struyf, F
Lehtinen, M
Dubin, G
Abstract: Background. Public Health England has reported a decrease of up to 20.8% in new diagnoses of external genital warts (GWs) among women aged <19 years since the national vaccination program with the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine began in 2008. A post hoc analysis of the phase III PATRICIA (PApilloma TRIal against Cancer In young Adults) trial (NCT00122681) was performed to ascertain whether protection against low-risk HPV types was apparent. Methods. Vaccine efficacy (VE) at 48 months was assessed against 6-month persistent infection (6MPI) with low-risk HPV types in the total vaccinated cohort (TVC) and in the TVC naive (for 25 HPV types tested) populations. Results. In the TVC naive cohort, VE against 6MPI (95% confidence interval) was 34.5% (11.3 to 51.8) for HPV6/11, 34.9% (9.1 to 53.7) for HPV-6, 30.3% (-45.0 to 67.5) for HPV-11, and 49.5% (21.0 to 68.3) for HPV-74. Conclusions. The HPV-16/18 AS04-adjuvanted vaccine appears to have moderate efficacy against persistent infections with a number of low-risk HPV types (HPV-6/11/74), which are responsible for the majority of external GWs, and recently, antibody and cell-mediated immune response to HPV-6/11 have been observed. These findings may help to explain the decrease in external GW diagnoses seen in England.
Subject: human papillomavirus
HPV vaccine
genital warts
Country: EUA
Editor: Oxford Univ Press Inc
Citation: Journal Of Infectious Diseases. Oxford Univ Press Inc, v. 208, n. 9, n. 1391, n. 1396, 2013.
Rights: fechado
Identifier DOI: 10.1093/infdis/jit360
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.