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Type: Artigo
Title: Efficacy of liposome-encapsulated mepivacaine for infiltrative anesthesia in volunteers
Author: Tofoli, G. R.
Cereda, C. M. S.
Groppo, F. C.
Volpato, M. C.
Franz-Montan, M.
Ranali, J.
de Araujo, D. R.
de Paula, E.
Abstract: This blinded crossover study evaluated the efficacy and pain sensitivity evoked by a previously reported liposome-encapsulated mepivacaine formulation (Araujo et al., 2004). Thirty healthy volunteers received an intraoral injection (1.8 mL), at four different sessions, of the following formulations:2% mepivacaine with 1:100,000 epinephrine (MVC2%EPI), 3% mepivacaine (MVC3%), and 2 and 3% liposome-encapsulated mepivacaine (MVC2%LUV and MVC3%LUV). Latency period and duration of anesthesia were assessed by an electrical pulp tester and injection discomfort by a visual analog scale (VAS). Data were analyzed with Tukey-Kramer and Friedman tests (P < 0.05). No significant difference was found regarding latency period (in minutes) among the formulations (P > 0.05). The duration of anesthesia after the injection of MVC3%LUV was higher than the one obtained after the infiltration of MVC2%LUV and of MVC3% (P < 0.05). However, the duration of anesthesia obtained with MVC3% did not differ from the one obtained with MVC2%LUV (P > 0.05). MVC3%LUV showed lower VAS median values than MVC2%EPI (P < 0.05), and there were no significant differences among the others formulations. Liposome-encapsulated 3% mepivacaine showed longer duration of anesthesia, in comparison to the commercial formulation of MVC3%. MVC2%LUV was able to produce a similar duration of anesthesia as the 3% commercial formulation, despite the 50% decrease in the anesthetic concentration. Thus, the encapsulation of mepivacaine increased the duration of anesthesia and reduced the injection discomfort caused by vasoconstrictor-associated formulations in healthy volunteers. Trial registration number of this study is NCT01032798
Subject: Lipossomos
Anestésicos locais
Country: Estados Unidos
Editor: Taylor & Francis
Citation: Journal Of Liposome Research. Informa Healthcare, v. 21, n. 1, n. 88, n. 94, 2011.
Rights: fechado
Identifier DOI: 10.3109/08982104.2010.483596
Date Issue: 2011
Appears in Collections:IB - Artigos e Outros Documentos
FOP - Artigos e Outros Documentos

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