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Type: Artigo de periódico
Title: Stimulation of soluble guanylyl cyclase by BAY 41-2272 relaxes anococcygeus muscle: Interaction with nitric oxide
Author: Teixeira, CE
Priviero, FBM
Claudino, MA
Baracat, JS
De Nucci, G
Webb, RC
Antunes, E
Abstract: The compound BAY 41-2272 stimulates the soluble guanylyl cyclase in a nitric oxide (NO)-independent manner. We have investigated the potency and efficacy of BAY 41-2272 in the rat anococcygeus muscle, as well as the effects of BAY 41-2272 on NO-mediated anococcygeus relaxations. BAY 41-2272 (0.01-10 mu M) potently relaxed precontracted anococcygeus muscle strips, with a pEC(50) value of 6.44 +/- 0.03 and maximum response of 100 +/- 2%. The soluble guanylyl cyclase inhibitor H-1-[1,2,4]-oxidiazolo[4,3-a] quinoxalin-1-one (ODQ, 1 mu M) and the NO inhibitor N-omega-nitro-L-arginine methyl ester (L-NAME, 100 mu M) caused significant rightward shifts in the concentration-response curves to BAY 41-2272. The phosphodiesterase type-5 inhibitor tadalafil (0.1 mu M) markedly enhanced the relaxations evoked by BAY 41-2272. In addition, BAY 41-2272 increased the duration of nitrergic relaxations by approximately 55%. The relaxations induced by glyceryl trinitrate were also significantly potentiated by BAY 41-2272. In conclusion, BAY 41-2272 interacts with endogenous and exogenous NO causing a potent relaxation of rat anococcygeus muscle. (c) 2005 Elsevier B.V. All rights reserved.
Subject: anococcygeus muscle
BAY 41-2272
soluble guanylyl cyclase
nitric oxide
nitrergic nerve
Country: Holanda
Editor: Elsevier Science Bv
Rights: fechado
Identifier DOI: 10.1016/j.ejphar.2005.11.015
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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