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Type: Artigo
Title: Stimulation of soluble guanylyl cyclase by BAY 41-2272 relaxes anococcygeus muscle: interaction with nitric oxide
Author: Teixeira, C.E.
Baracat, J.S.
Claudino, M.A.
Priviero, F.B.M.
De Nucci, G.
Antunes, E.
Webb, R.C.
Abstract: The compound BAY 41-2272 stimulates the soluble guanylyl cyclase in a nitric oxide (NO)-independent manner. We have investigated the potency and efficacy of BAY 41-2272 in the rat anococcygeus muscle, as well as the effects of BAY 41-2272 on NO-mediated anococcygeus relaxations. BAY 41-2272 (0.01-10 mu M) potently relaxed precontracted anococcygeus muscle strips, with a pEC(50) value of 6.44 +/- 0.03 and maximum response of 100 +/- 2%. The soluble guanylyl cyclase inhibitor H-1-[1,2,4]-oxidiazolo[4,3-a] quinoxalin-1-one (ODQ, 1 mu M) and the NO inhibitor N-omega-nitro-L-arginine methyl ester (L-NAME, 100 mu M) caused significant rightward shifts in the concentration-response curves to BAY 41-2272. The phosphodiesterase type-5 inhibitor tadalafil (0.1 mu M) markedly enhanced the relaxations evoked by BAY 41-2272. In addition, BAY 41-2272 increased the duration of nitrergic relaxations by approximately 55%. The relaxations induced by glyceryl trinitrate were also significantly potentiated by BAY 41-2272. In conclusion, BAY 41-2272 interacts with endogenous and exogenous NO causing a potent relaxation of rat anococcygeus muscle
Subject: Óxido nítrico
Neurônios nitrérgicos
Country: Países Baixos
Editor: Elsevier
Citation: European Journal Of Pharmacology. Elsevier Science Bv, v. 530, n. 41671, n. 157, n. 165, 2006.
Rights: fechado
Identifier DOI: 10.1016/j.ejphar.2005.11.015
Date Issue: 2006
Appears in Collections:FCM - Artigos e Outros Documentos

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