Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/79867
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampFerreira, Tatianept_BR
dc.contributor.authorunicampLanducci, Elen Cristina Teizempt_BR
dc.contributor.authorunicampAntunes, Edsonpt_BR
dc.contributor.authorunicampDe Nucci, Gilbertopt_BR
dc.typeArtigopt_BR
dc.titleRole of substance P and bradykinin in acute pancreatitis induced by secretory phospholipase A(2)pt_BR
dc.contributor.authorCamargo, E.A.pt_BR
dc.contributor.authorFerreira, T.pt_BR
dc.contributor.authorRibela, M.T.C.P.pt_BR
dc.contributor.authorLanducci, E.C.T.pt_BR
dc.contributor.authorAntunes, E.pt_BR
dc.contributor.authorDe Nucci, G.pt_BR
dc.subjectFosfolipases A2pt_BR
dc.subjectReceptores da neurocinina-1pt_BR
dc.subject.otherlanguagePhospholipases A2pt_BR
dc.subject.otherlanguageReceptors, neurokinin-1pt_BR
dc.description.abstractSecretory phospholipases A(2) (sPLA(2)s) induce acute pancreatitis when injected into the common bile duct of rats. Substance P via neurokinin 1 (NK-1) receptors and bradykinin via B-2 receptors are described to play important roles in the pathophysiology of acute pancreatitis. This study was undertaken to evaluate the role of substance P and bradykinin in the sPLA(2)-induced pancreatitis. Methods: Rats were submitted to the common bile duct injection of sPLA(2) obtained from Naja mocambique mocambique venom at 300 mu g/kg. At 4 hours thereafter, measurement of pancreatic plasma extravasation, pancreatic and lung myeloperoxidase (MPO), serum amylase, and serum tumor necrosis factor alpha levels were evaluated. Results: Injection of sPLA(2) significantly increased all parameters evaluated. Pretreatment with either the NK-1 receptor antagonist SR140333 or the B-2 receptor antagonist icatibant largely reduced the increased pancreatic plasma extravasation and circulating levels of tumor necrosis factor alpha. Both treatments partly reduced the MPO levels in the pancreas, whereas in the lungs, icatibant was more efficient to reduce the increased MPO levels. In addition, icatibant largely reduced the serum levels of amylase, whereas SR140333 had no significant effect. Conclusions: We concluded that NK-1 and B-2 receptors can regulate important steps in the local and remote inflammation during acute pancreatitis induced by sPLA(2)pt
dc.description.eventLippincott Williams & Wilkinspt_BR
dc.relation.ispartofPancreaspt_BR
dc.relation.ispartofabbreviationPancreaspt_BR
dc.publisher.cityPhiladelphia, PApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherLippincott Williams & Wilkinspt_BR
dc.date.issued2008pt_BR
dc.date.monthofcirculationJulypt_BR
dc.identifier.citationPancreas. Lippincott Williams & Wilkins, v. 37, n. 1, n. 50, n. 55, 2008.pt_BR
dc.language.isoengpt_BR
dc.description.volume37pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage50pt_BR
dc.description.lastpage55pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0885-3177pt_BR
dc.identifier.eissn1536-4828pt_BR
dc.identifier.doi10.1097/MPA.0b013e3185d9b9bpt_BR
dc.identifier.urlhttps://insights.ovid.com/crossref?an=00006676-200807000-00008pt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsorship1FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.date.available2014-11-17T08:07:18Z
dc.date.available2015-11-26T16:41:23Z-
dc.date.accessioned2014-11-17T08:07:18Z
dc.date.accessioned2015-11-26T16:41:23Z-
dc.description.provenanceMade available in DSpace on 2014-11-17T08:07:18Z (GMT). No. of bitstreams: 1 WOS000257289400008.pdf: 294389 bytes, checksum: 82640e6ee6dc296840c03d0dd9bd8dd9 (MD5) Previous issue date: 2008 Bitstreams deleted on 2020-05-18T20:40:59Z: WOS000257289400008.pdf,. Added 1 bitstream(s) on 2020-05-19T14:30:45Z : No. of bitstreams: 2 000257289400008.pdf: 372107 bytes, checksum: 5809048bfe2b98d09b846ae6fe47ff32 (MD5) WOS000257289400008.pdf.txt: 32073 bytes, checksum: 84a44bd94b1f47001d23eab4f313b9c7 (MD5)en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:41:23Z (GMT). No. of bitstreams: 2 WOS000257289400008.pdf: 294389 bytes, checksum: 82640e6ee6dc296840c03d0dd9bd8dd9 (MD5) WOS000257289400008.pdf.txt: 32073 bytes, checksum: 84a44bd94b1f47001d23eab4f313b9c7 (MD5) Previous issue date: 2008en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/79867pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/79867
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/79867-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.source000257289400008-
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-2201-8247pt_BR
dc.creator.orcid0000-0002-4346-7941pt_BR
dc.type.formArtigo originalpt_BR
dc.description.eventsponsorPhiladelphia, PApt_BR
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