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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleEffects of trifluoperazine on the conformation and dynamics of membrane proteins in human erythrocytespt_BR
dc.contributor.authorRuggiero, ACpt_BR
dc.contributor.authorMeirelles, NCpt_BR
unicamp.authorUNICAMP, Inst Biol, Dept Bioquim, BR-13801 Campinas, SP, Brazil UNIMEP, Ctr Ciencias Exatas, Dept Quim, BR-13400901 Piracicaba, SP, Brazilpt_BR
dc.subjecttrifluoperazinept_BR
dc.subjecterythrocyte membranept_BR
dc.subjectfluorescencept_BR
dc.subject.wosChlorpromazinept_BR
dc.subject.wosPhenothiazinespt_BR
dc.description.abstractThe chemical modifications induced by trifluoperazine (TFP) in erythrocyte ghosts have been investigated by fluorescence quenching. The apparent distance separating the membrane protein tryptophans and bound 1-aniline-8-naphthalene sulfonate (ANS) molecules decreased after treating erythrocyte membranes with TFP. This effect was accompanied by a significant decrease in the maximum efficiency of energy transfer. We conclude that TFP-induced alterations in the structure of membrane proteins lead to a rearrangement of the surrounding lipids, and consequently to local conformational changes in membrane organization. (C) 1998 Academic Press.pt
dc.relation.ispartofMolecular Genetics And Metabolismpt_BR
dc.relation.ispartofabbreviationMol. Genet. Metab.pt_BR
dc.publisher.citySan Diegopt_BR
dc.publisher.countryEUApt_BR
dc.publisherAcademic Press Incpt_BR
dc.date.issued1998pt_BR
dc.date.monthofcirculationJUNpt_BR
dc.identifier.citationMolecular Genetics And Metabolism. Academic Press Inc, v. 64, n. 2, n. 148, n. 151, 1998.pt_BR
dc.language.isoenpt_BR
dc.description.volume64pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage148pt_BR
dc.description.lastpage151pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1096-7192pt_BR
dc.identifier.wosidWOS:000075520300007pt_BR
dc.identifier.doi10.1006/mgme.1998.2689pt_BR
dc.date.available2014-12-02T16:25:29Z
dc.date.available2015-11-26T16:18:00Z-
dc.date.accessioned2014-12-02T16:25:29Z
dc.date.accessioned2015-11-26T16:18:00Z-
dc.description.provenanceMade available in DSpace on 2014-12-02T16:25:29Z (GMT). No. of bitstreams: 1 WOS000075520300007.pdf: 89712 bytes, checksum: 0109c0e25c9a9adf08f7208ca50e222c (MD5) Previous issue date: 1998en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:18:00Z (GMT). No. of bitstreams: 2 WOS000075520300007.pdf: 89712 bytes, checksum: 0109c0e25c9a9adf08f7208ca50e222c (MD5) WOS000075520300007.pdf.txt: 15477 bytes, checksum: 562e46be6e7a5c1f9a4756af0efad02d (MD5) Previous issue date: 1998en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/79776pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/79776
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/79776-
Appears in Collections:Unicamp - Artigos e Outros Documentos

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