Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/79738
Type: Artigo de periódico
Title: EBV-Associated Polymorphic Posttransplant Lymphoproliferative Disorder Presenting as Gingival Ulcers
Author: Leon, JE
Takahama, A
Vassallo, J
Soares, FA
de Almeida, OP
Lopes, MA
Abstract: Posttransplant lymphoproliferative disorders (PTLDs) present a wide clinicopathological spectrum, varying from the usual Epstein-Barr virus (EBV)-driven infectious mononucleosis-type polyclonal proliferations to EBV-positive or EBV-negative proliferations indistinguishable from overt lymphomas that occur in immunocompetent individuals. PTLDs characteristically have a predilection for extranodal sites and association with EBV. These disorders are usually B-cell type, although T-cell and rare cases involving both T-and B-cell types have also been described. The initial treatment consists in decreasing the immnosupressive therapy, usually with favorable results. The authors report on a rare case of a 19-year-old girl, with post-renal transplantation EBV-associated polymorphic lymphoproliferative gingival ulcerated lesions. To the best of their knowledge, this is the first case described in the English-language literature of polymorphic PTLD involving both B-cell and T-cell lineages, with an unusual immunoprofile affecting the mouth. The authors warn that this condition could be easily misdiagnosed as malignant lymphoma if not properly recognized.
Subject: oral ulcers
posttransplant
EBV
immunohistochemistry
Country: EUA
Editor: Sage Publications Inc
Rights: fechado
Identifier DOI: 10.1177/1066896909353599
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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