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Type: Artigo de periódico
Title: Disarray of glomerular and tubular cell adhesion molecules in the course of experimental Bothrops moojeni envenomation
Author: Collares-Buzato, CB
da Cruz-Hofling, MA
Abstract: In this study, we show that administration of Bothrops moojeni venom in rats induces a general disturbance in the distribution and content of the tight junctional protein ZO-1, the cell-matrix receptor beta 1 integrin, the cytoskeletal proteins, vinculin and F-actin, and of the extracellular matrix component laminin in renal corpuscles and cortical nephron tubules. These findings suggest that cell-cell and cell-matrix adhesion proteins may be molecular targets in the B. moojeni-induced kidney injury. (C) 2013 Elsevier Ltd. All rights reserved.
Subject: Acute kidney injury
Bothropic envenomation
Cell adhesion proteins
Cytoskeletal proteins
Glomerular injury
Nephron tubular injury
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/j.toxicon.2013.11.013
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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