Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/796
Type: Artigo de periódico
Title: Different circulating metalloproteinases profiles in women with migraine with and without aura
Author: MARTINS-OLIVEIRA, Alisson
SPECIALI, Jose G.
DACH, Fabiola
MARCACCINI, Andrea M.
GONCALVES, Flavia M.
GERLACH, Raquel F.
TANUS-SANTOS, J. E.
Abstract: Background: We compared the circulating levels of matrix metalloproteinase (MMP)-2. MMP-9, tissue inhibitors of metal loproteinase (TIMP)-1, TIMP-2, and MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios in migraine patients without aura (MWA) and in migraine patients with aura (MA) with those found in healthy subjects (controls). Methods: We studied 80 migraine (40 MWA and 40 MA) women and 40 controls. Pro-MMP-2 levels were determined by zymography and MMP-9, TIMP-1, and TIMP-2 levels were determined by ELISA. Results: While we found similar TIMP-2 levels, higher plasma pro-MMP-2 and pro-MMP-2/TIMP-2 ratios were found in MWA and MA patients compared with controls (P<0.05). Higher TIMP-1 levels and lower MMP-9/TIMP-1 ratio were found in MA, but not in MWA, patients compared with controls (P<0.05). We found no significant differences when patients without headache attack were compared with patients having a headache attack (all P<0.05). Conclusions: We showed an increased net MMP-2 activity in MWA and MA. The increased MMP-9/TIMP-1 ratios in MWA patients contrast with the lower MMP-9/TIMP-1 ratios in MA patients and may reflect pathophysiological differences between these conditions. (C) 2009 Elsevier B.V. All rights reserved.
Subject: Migraine
Metalloproteinases
Tissue inhibitors of metalloproteinases
Country: Holanda
Editor: ELSEVIER SCIENCE BV
Rights: fechado
Identifier DOI: 10.1016/j.cca.2009.07.008
Address: http://dx.doi.org/10.1016/j.cca.2009.07.008
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Date Issue: 2009
Appears in Collections:FCM - Artigos e Materiais de Revistas Científicas

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