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Type: Artigo de periódico
Title: Dendritic cell activation and maturation induced by mucosal fluid from women with bacterial vaginosis
Author: John, EPS
Martinson, J
Simoes, JA
Landay, AL
Spear, GT
Abstract: Dendritic cells (DC) at mucosal surfaces mature when exposed to 'danger' signals such as LPS. Bacterial, vaginosis (BV) is a prevalent alteration of the vaginal bacterial. flora associated with preterm childbirth and increased risk for HIV acquisition. We examined the effect of mucosal fluid from women with BV or healthy flora on DC function. IL-12, IL-23 and p40 production by monocyte-derived dendritic cells (MDDC) were all induced by BV samples. Activation/maturation markers HLA-DR, CD40 and CD83 on MDDC incubated with BV CVL were also induced. BV CVL also decreased the endocytic ability of MDDC and increased proliferation of T cells in allogeneic MLR. Plasmacytoid dendritic cell (pDC) CD86 expression was induced by BV CVL. Healthy flora CVL had little effect in any of the tests. This study suggests that BV, but not healthy flora, affects local dendritic cell function in vivo suggesting a mechanism through which BV affects mucosal immunity. (c) 2007 Elsevier Inc. All rights reserved.
Subject: myeloid dendritic cells
plasmacytoid dendritic cells
bacterial vaginosis
bacterial flora
antigen presentation
mucosal immunity
Country: EUA
Editor: Academic Press Inc Elsevier Science
Citation: Clinical Immunology. Academic Press Inc Elsevier Science, v. 125, n. 1, n. 95, n. 102, 2007.
Rights: fechado
Identifier DOI: 10.1016/j.clim.2007.06.004
Date Issue: 2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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