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Type: Artigo de periódico
Title: Delayed first injection of a once-a-month injectable contraceptive containing 25 mg of medroxyprogesterone acetate and 5 mg of E(2)-cypionate: effects on ovarian function
Author: Petta, CA
Hays, M
Brache, V
Massai, R
Hua, Y
Alvarez-Sanchez, F
Croxatto, H
d'Arcangues, C
Cook, LA
Bahamondes, L
Abstract: Objective: To assess whether women who were administered the first injection of DMPAcE+E(2)C on day 7 of their menstural cycle (delayed injection) exhibit the same degree of ovarian suppression as women who receive it on day 5 of their menstrual cycle. Design: Multicenter, randomized controlled trial. Setting: Reproductive health clinics. Patient(s): Women aged between 18 and 38 years (inclusive) willing to use DMPA+E(2)C as their method of a contraception. Intervention(s): Participants received a DMPA+E(2)C injection an day 5 (control group, n = 41) or day 7 (delayed-injection group, n = 117) of their menstrual cycle. Main Outcome Measure(s): Ovarian activity and follicular development determined by serial serum progesterone levels and vaginal ultrasound. Result(s): Participants who received DMPA+E(2)C on day 5 of their menstrual cycle (control group) exhibited no more than limited follicular growth (no follicle > 16 mm). Of those women who received DMPA+E(2)C on day 7 of their menstrual cycle (delayed-injection group), 21 (18%) showed some follicular growth, of whom 4 (3%) ovulated. Conclusion(s): The first injection of DMPA+E(2)C given on day 7 of a menstrual cycle does not provide the same inhibition of ovarian activity as that observed when it is administered on day 5 of the menstrual cycle. (Fertil Steril (R) 2001;75:744-8 (C) 2001 by American Society for Reproductive Medicine.).
Subject: cyclofem
randomized controlled trial
Country: EUA
Editor: Elsevier Science Inc
Citation: Fertility And Sterility. Elsevier Science Inc, v. 75, n. 4, n. 744, n. 748, 2001.
Rights: fechado
Identifier DOI: 10.1016/S0015-0282(01)01672-7
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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