Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/794
Type: Artigo de periódico
Title: Reproductive development and function of female rats exposed to di-eta-butyl-phthalate (DBP) in utero and during lactation
Author: GUERRA, Marina T.
SCARANO, Wellerson R.
TOLEDO, Fabiola C. de
FRANCI, Janete A. A.
KEMPINAS, Wilma De G.
Abstract: Phthalates are environmental contaminants used in the production of plastics, cosmetics and medical devices. Studies on the effects of phthalates on female reproductive health are particularly sparse and mostly restricted to high-dose exposure in rats. In the present study, pregnant rats were treated with 100 mg/kg-d of di-eta-butyl-phthalate (DBP) or only the vehicle (control group), from GD 12 to GD 20 for evaluation of reproductive outcomes and fetal gonads analysis (F0), and from GD 12 to PND 21 to evaluate reproductive development and function on F1 female offspring. Results showed that all parameters were comparable between groups, although there was a significant increase in the fetal weight after DBP exposure. However, the body weight at birth was normal. Based on these data we can conclude that, in these experimental conditions, DBP did not disturb the reproductive development or function of female rats. (C) 2009 Elsevier Inc. All rights reserved.
Subject: Maternal exposure
Di-eta-butyl-phthalate
Female offspring
Reproduction
Uterus
Ovary
Estrous cycle
Sexual behavior
Country: Inglaterra
Editor: PERGAMON-ELSEVIER SCIENCE LTD
Citation: REPRODUCTIVE TOXICOLOGY, v.29, n.1, p.99-105, 2010
Rights: fechado
Identifier DOI: 10.1016/j.reprotox.2009.10.005
Address: http://dx.doi.org/10.1016/j.reprotox.2009.10.005
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Date Issue: 2010
Appears in Collections:IB - Artigos e Materiais de Revistas Científicas

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