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Type: Artigo de periódico
Title: Deficiency in microfibril-associated glycoprotein-1 leads to complex phenotypes in multiple organ systems
Author: Weinbaum, JS
Broekelmann, TJ
Pierce, RA
Werneck, CC
Segade, F
Craft, CS
Knutsen, RH
Mecham, RP
Abstract: Microfibril-associated glycoprotein-1 (MAGP-1) is a small molecular weight component of the fibrillin-rich microfibril. Gene-targeted inactivation of MAGP-1 reveals a complex phenotype that includes increased body weight and size due to excess body fat, an altered wound healing response in bone and skin, and a bleeding diathesis. Elastic tissues rich in MAGP-1-containing microfibrils develop normally and show normal function. The penetrance of MAGP-1-null phenotypes is highly variable and mouse strain-dependent, suggesting the influence of modifier genes. MAGP-1 was found to bind active transforming growth factor-beta(TGF-beta) and BMP-7 with high affinity, suggesting that it may be an important modulator of microfibril-mediated growth factor signaling. Many of the phenotypic traits observed in MAGP-1-deficient mice are consistent with loss of TGF-beta function and are generally opposite those associated with mutations in fibrillin-1 that result in enhanced TGF-beta signaling. Increased body size and fat deposition in MAGP-1-mutant animals are particularly intriguing given the localization of obesity traits in humans to the region on chromosome 1 containing the MAGP-1 gene.
Country: EUA
Editor: Amer Soc Biochemistry Molecular Biology Inc
Citation: Journal Of Biological Chemistry. Amer Soc Biochemistry Molecular Biology Inc, v. 283, n. 37, n. 25533, n. 25543, 2008.
Rights: fechado
Identifier DOI: 10.1074/jbc.M709962200
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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