Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/79364
Type: Artigo de periódico
Title: Default Mode, Executive Function, and Language Functional Connectivity Networks are Compromised in Mild Alzheimer's Disease
Author: Weiler, M
Fukuda, A
Massabki, LHP
Lopes, TM
Franco, AR
Damasceno, BP
Cendes, F
Balthazar, MLF
Abstract: Alzheimer's disease (AD) is characterized by mental and cognitive problems, particularly with memory, language, visuospatial skills (VS), and executive functions (EF). Advances in the neuroimaging of AD have highlighted dysfunctions in functional connectivity networks (FCNs), especially in the memory related default mode network (DMN). However, little is known about the integrity and clinical significance of FNCs that process other cognitive functions than memory. We evaluated 22 patients with mild AD and 26 healthy controls through a resting state functional MRI scan. We aimed to identify different FCNs: the DMN, language, EF, and VS. Seed-based functional connectivity was calculated by placing a seed in the DMN (posterior cingulate cortex), language (Broca's and Wernicke's areas), EF (right and left dorsolateral prefrontal cortex), and VS networks (right and left associative visual cortex). We also performed regression analyses between individual connectivity maps for the different FCNs and the scores on cognitive tests. We found areas with significant decreases in functional connectivity in patients with mild AD in the DMN and Wernicke's area compared with controls. Increased connectivity in patients was observed in the EF network. Regarding multiple linear regression analyses, a significant correlation was only observed between the connectivity of the DMN and episodic memory (delayed recall) scores. In conclusion, functional connectivity alterations in mild AD are not restricted to the DMN. Other FCNs related to language and EF may be altered. However, we only found significant correlations between cognition and functional connectivity in the DMN and episodic memory performance.
Subject: Alzheimer's disease
cognition
default mode network
functional connectivity
functional networks
resting-state networks
Country: Emirados Árabes Unidos
Editor: Bentham Science Publ Ltd
Rights: fechado
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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