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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleDecreased TNF-alpha gene expression in periodontal ligature in MSG-obese rats: A possible protective effect of hypothalamic obesity against periodontal disease?pt_BR
dc.contributor.authorBrandelero, Spt_BR
dc.contributor.authorBonfleur, MLpt_BR
dc.contributor.authorRibeiro, RApt_BR
dc.contributor.authorVanzela, ECpt_BR
dc.contributor.authorNassar, CApt_BR
dc.contributor.authorNassar, POpt_BR
dc.contributor.authorBalbo, SLpt_BR
unicamp.author.emailslbalbo@hotmail.compt_BR
unicamp.authorBrandelero, Savio, Jr. Bonfleur, Maria Lucia Nassar, Carlos Augusto Nassar, Patricia Oehlmeyer Balbo, Sandra Lucinei Univ State W Parana UNIOESTE, Biol Sci & Hlth Ctr, Cascavel, Parana, Brazilpt_BR
unicamp.authorRibeiro, Rosane Aparecida Univ Fed Rio de Janeiro, Ctr Ecol & Socioenvironm NUPEM, Integrated Lab Biochem Hatisaburo Masuda, Rio De Janeiro, RJ, Brazilpt_BR
unicamp.authorVanzela, Emerielle Cristine State Univ Campinas UNICAMP, Dept Anat Cellular Biol Physiol & Biofis, Sao Paulo, Brazilpt_BR
dc.subjectObesitypt_BR
dc.subjectMonosodium glutamatept_BR
dc.subjectPeriodontal diseasept_BR
dc.subject.wosMonosodium Glutamatept_BR
dc.subject.wosInsulin-resistancept_BR
dc.subject.wosNeonatal Treatmentpt_BR
dc.subject.wosBone Homeostasispt_BR
dc.subject.wosAdipose-tissuept_BR
dc.subject.wosCell-functionpt_BR
dc.subject.wosSerum Leptinpt_BR
dc.subject.wosTreated-ratspt_BR
dc.subject.wosAdult-ratspt_BR
dc.subject.wosSecretionpt_BR
dc.description.abstractThe prevalence of obesity is increasing globally. There is evidence that the uncontrolled energetic metabolism in obese patients can accelerate periodontal disease. Therefore, the aim of this study was evaluate the possible relationship between hypothalamic obesity induced by neonatal treatment with MSG and experimental periodontal disease. Newborn male Wistar rats received subcutaneous injections in the cervical region, of 4g/Kg/day of body weight (BW) of MSG (MSG group) or hypertonic saline solution, 1.25/kg/day BW (control group, CTL). At 70 days of life periodontal disease was induced in these animals. After they were sacrificed, radiographic analyses of alveolar bone resorption and Tumor Necrosis Factor alpha (TNF alpha) gene expression in gingival tissue were performed. The neonatal treatment with MSG did not affect the concentration of plasma glucose and cholesterol (CHOL). However, plasma insulin, non-esterified fatty acids (NEFA) and triglycerides (TG) leves were higher in MSG compared with CTL group. The alveolar bone resorption was 44% lower in MSG-obese rats compared with CTL rats. In the presence of periodontal ligature, there was an increase in this parameter in all groups. The TNF alpha gene expression, an inflammatory marker, in periodontal tissue was similar in obese and CTL rats. The presence of ligature increased TNF alpha gene expression in both groups, but in a lower extension in MSG-obese rats. In conclusion these results suggested that hypothalamic obesity may produce a protective effect against periodontal disease, however further research is needed to understand the mechanisms involved in this process. (C) 2011 Elsevier Ltd. All rights reserved.pt
dc.relation.ispartofArchives Of Oral Biologypt_BR
dc.relation.ispartofabbreviationArch. Oral Biol.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherPergamon-elsevier Science Ltdpt_BR
dc.date.issued2012pt_BR
dc.date.monthofcirculationMARpt_BR
dc.identifier.citationArchives Of Oral Biology. Pergamon-elsevier Science Ltd, v. 57, n. 3, n. 300, n. 306, 2012.pt_BR
dc.language.isoenpt_BR
dc.description.volume57pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage300pt_BR
dc.description.lastpage306pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0003-9969pt_BR
dc.identifier.wosidWOS:000301995800013pt_BR
dc.identifier.doi10.1016/j.archoralbio.2011.08.024pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipUniversity of State of West of Parana (UNIOESTE), Brazilpt_BR
dc.description.sponsorshipState University of Campinas (UNICAMP), Brazilpt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.date.available2014-08-01T18:28:00Z
dc.date.available2015-11-26T17:00:27Z-
dc.date.accessioned2014-08-01T18:28:00Z
dc.date.accessioned2015-11-26T17:00:27Z-
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dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/79354
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/79354-
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