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Type: Artigo de periódico
Title: Decreased GATA3 mRNA expression in human T-cell lymphotropic virus type 1 (HTLV-1) infection
Author: Gilli, SCO
Salles, TSI
Saad, STO
Abstract: GATA3 is a specific T-cell transcription factor involved in the expression of T-cell receptor (TCR). In order to characterize the relationship between HTLV-I infection, which has been reported to he associated with down-regulation of genes belonging to the TCR/CD3 complex, and the transcription factor GATA3, we evaluated, by semi-quantitative RT-PCR, the expression of GATA3 gene in HTLV-1 carriers and individuals with related diseases. The study included 4 asymptomatic carriers, 2 patients with adult T-cell leukaemia/lymphoma (ATLL), 1 patient with HTLV-1 associated myelopathy (HAM)/tropical spastic paraparesis (TSP) and 7 healthy blood donors. A considerable decrease in the expression of the GATA3 mRNA was observed in all subjects infected by HTLV-1 and no expression of GATA3 mRNA was observed in 1 subject with ATLL and in 1 with HAM/TSP.
Country: Noruega
Editor: Taylor & Francis As
Citation: Scandinavian Journal Of Infectious Diseases. Taylor & Francis As, v. 32, n. 2, n. 161, n. 163, 2000.
Rights: fechado
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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