Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/79345
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleDecrease of type IV collagen and TIMP-1 serum levels after splenectomy in patients with schistosomiasis mansonipt_BR
dc.contributor.authorWyszomirska, RMAFpt_BR
dc.contributor.authorLacet, CDpt_BR
dc.contributor.authorTenorio, LRpt_BR
dc.contributor.authorNishimura, NFpt_BR
dc.contributor.authorMesquita, MApt_BR
dc.contributor.authorNeto, JBpt_BR
dc.contributor.authorOliveira, Fpt_BR
dc.contributor.authorBalwani, MDCLpt_BR
dc.contributor.authorAlmeida, JRSpt_BR
dc.contributor.authorSoares, ECpt_BR
unicamp.author.emailrozangelaf@uol.com.brpt_BR
unicamp.authorUniv Alagoas, Dept Internal Med, Maceio, AL, Brazil Univ Estadual Campinas, Fac Med Sci, Gastroctr, Campinas, SP, Brazil Univ Alagoas, Dept Surg, BR-57035030 Maceio, AL, Brazil Univ Alagoas, Dept Pathol, BR-57035030 Maceio, AL, Brazilpt_BR
dc.subjectschistosomiasis mansonipt_BR
dc.subjectTIMP-1pt_BR
dc.subjecttype IV collagenpt_BR
dc.subjectspleenpt_BR
dc.subjectliver fibrosispt_BR
dc.subject.wosT-cell-activationpt_BR
dc.subject.wosLiver Fibrosispt_BR
dc.subject.wosHepatosplenic Schistosomiasispt_BR
dc.subject.wosMurine Schistosomiasispt_BR
dc.subject.wosMatrix Metalloproteinasespt_BR
dc.subject.wosSpleenpt_BR
dc.subject.wosExpressionpt_BR
dc.subject.wosInhibitorspt_BR
dc.subject.wosMarkerspt_BR
dc.subject.wosGranulomapt_BR
dc.description.abstractThe role of the spleen in the process of liver fibrosis in schistosomiasis still needs clarification. The aim of this Study was to assess the effect of splenectomy on serum levels of two markers of fibrosis, type IV collagen and TIMP-1, in patients with schistosomiasis mansoni. Twenty-four patients with hepatosplenic schistosomiasis mansoni participated in the study. Type IV collagen and TIMP-1 serum levels were measured preoperatively, and after 2 (POD-1) and 60 days (POD-2) of spleen removal. Before splenectomy, both type IV collagen and TIMP-1 serum levels were elevated in the majority of patients. After splenectomy, the levels of type IV collagen showed a significant decrease in relation to the preoperative values both in POD-1 (median pre-splenectomy: 143.7 ng/ml versus 77.01 ng/ml p = 0.04) and POD-2 (103.3 ng/ml; p = 0.015). Serum levels of TIMP-1 also showed a significant decrease in relation to the preoperative values both in POD-1 (pre-splenectomy: 585.9 ng/ml versus 196.4 ng/ml; p = 0.008) and POD-2 (97.4 ng/ml; p < 0.001). There was no difference between POD-land POD-2 values for each serum marker. In conclusion, splenectomy in schistosomotic patients was associated with it decrease in serum markers of fibrosis levels, which persisted for at least 60 days. These results suggest that the spleen may play a role in the extra cellular matrix production, and therefore may contribute to liver fibrosis in schistosomiasis mansoni. (c) 2006 Elsevier B.V. All rights reserved.pt
dc.relation.ispartofActa Tropicapt_BR
dc.relation.ispartofabbreviationActa Trop.pt_BR
dc.publisher.cityAmsterdampt_BR
dc.publisher.countryHolandapt_BR
dc.publisherElsevier Science Bvpt_BR
dc.date.issued2006pt_BR
dc.date.monthofcirculationMARpt_BR
dc.identifier.citationActa Tropica. Elsevier Science Bv, v. 97, n. 3, n. 301, n. 308, 2006.pt_BR
dc.language.isoenpt_BR
dc.description.volume97pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage301pt_BR
dc.description.lastpage308pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0001-706Xpt_BR
dc.identifier.wosidWOS:000236505300009pt_BR
dc.identifier.doi10.1016/j.actatropica.2005.12.004pt_BR
dc.date.available2014-11-15T22:57:39Z
dc.date.available2015-11-26T17:22:27Z-
dc.date.accessioned2014-11-15T22:57:39Z
dc.date.accessioned2015-11-26T17:22:27Z-
dc.description.provenanceMade available in DSpace on 2014-11-15T22:57:39Z (GMT). No. of bitstreams: 1 WOS000236505300009.pdf: 165874 bytes, checksum: c40800a47ed5459041d44da55ebe80ff (MD5) Previous issue date: 2006en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:22:27Z (GMT). No. of bitstreams: 2 WOS000236505300009.pdf: 165874 bytes, checksum: c40800a47ed5459041d44da55ebe80ff (MD5) WOS000236505300009.pdf.txt: 35638 bytes, checksum: 5aaa105623efab2125480a37927c5908 (MD5) Previous issue date: 2006en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/79345pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/79345
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/79345-
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
WOS000236505300009.pdf161.99 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.