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Type: Artigo de periódico
Title: Synthesis, Antitumor and Antimicrobial Activity of Novel 1-Substituted Phenyl-3-[3-alkylamino(methyl)-2-thioxo-1,3,4-oxadiazol-5-yl] beta-Carboline Derivatives
Author: Savariz, FC
Formagio, ASN
Barbosa, VA
Foglio, MA
de Carvalho, JE
Duarte, MCT
Dias, BP
Sarragiotto, MH
Abstract: With the purpose of activity enhancement of 1-substituted phenyl-3-(2-thioxo-1,3,4-oxadiazol-5-yl) beta-carbolines 1a-c, reported as potential antitumor agents in our previous study, herein we report the synthesis and antitumor activity evaluation of several novel Mannich bases 2-7(a-c), by the introduction of different alkylamino(methyl) groups in the 1,3,4-oxadiazole unity of 1a-c. The antimicrobial activities of 1a-c and of 2-7(a-c) were also evaluated. Additionally, an in silico study of the ADME properties of novel synthesized beta-carboline derivatives 2-7(a-c) was performed by evaluation of their Lipinski's parameters and topological polar surface area (TPSA) and percentage of absorption (% ABS) data.
Subject: 1,3-disubstituted beta-carboline derivatives
Mannich bases
antitumor activity
antimicrobial activity
Country: Brasil
Editor: Soc Brasileira Quimica
Citation: Journal Of The Brazilian Chemical Society. Soc Brasileira Quimica, v. 21, n. 2, n. 288, n. U175, 2010.
Rights: aberto
Identifier DOI: 10.1590/S0103-50532010000200014
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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