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Type: Artigo de periódico
Title: Synthesis, antimycobacterial activities and cytotoxicity on V79 of 3-[4 '-Y-(1,1 '-biphenyl)-4-yl]-N,N-dimethyl-3-(4-X-phenyl)-2-propen-1-amine derivatives
Author: de Souza, AO
Junior, RRS
Ferreira-Julio, JF
Rodriguez, JA
Melo, PS
Haun, M
Sato, DN
Duran, N
Abstract: The derivatives of 3-(4'-bromo-[1,1'-biphenyl]-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2-propen-1-amine (5a-m) were synthesised through a Friedel-Crafts acylation followed by Wittig reaction. The effects of the compounds on standard strains or Mycobacterium sp. (ATCC) and V. tuberculosis isolated from clinical specimens were evaluated. Also the toxicity was determined on V79 cells line using neutral red uptake (NRU), nucleic acid content (NAC) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) reduction to measure the cellular viability. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
Subject: synthesis
V79 cells
antimycobacterial activity
Country: França
Editor: Editions Scientifiques Medicales Elsevier
Citation: European Journal Of Medicinal Chemistry. Editions Scientifiques Medicales Elsevier, v. 36, n. 10, n. 843, n. 850, 2001.
Rights: fechado
Identifier DOI: 10.1016/S0223-5234(01)01263-6
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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