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|Title:||Synthesis, anti-inflammatory and antimicrobial activities of new 1,2,4-oxadiazoles peptidomimetics|
Oliveira, C.F. de
Faria, A.R. de
|Abstract:||A new series of 1,2,4-oxadizoles 6a-g have been synthesised in good yields using the peptide synthesis strategy. The prepared compounds were tested for anti-inflammatory and antimicrobial activities. The anti-inflammatory activities were determined in the rat paw oedema induced by carrageenin. Compounds 6a, c, f and g (i.v.) significantly inhibited the rat paw oedema induced by carrageenin depending upon the dose employed. The compounds were also evaluated for their in vitro antimicrobial activity. Some compounds were found to have significant activity against Gram positive and Gram negative microorganisms|
|Citation:||Farmaco. Elsevier Science Sa, v. 55, n. 41984, n. 719, n. 724, 2000.|
|Appears in Collections:||FCM - Artigos e Outros Documentos|
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