Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/79272
Type: Artigo de periódico
Title: Synthesis, anti-inflammatory and antimicrobial activities of new 1,2,4-oxadiazoles peptidomimetics
Author: Leite, ACL
Vieira, RF
de Faria, AR
Wanderley, AG
Afiatpour, P
Ximenes, ECPA
Srivastava, RM
de Oliveira, CF
Medeiros, MV
Antunes, E
Brondani, DJ
Abstract: A new series of 1,2,4-oxadizoles 6a-g have been synthesised in good yields using the peptide synthesis strategy. The prepared compounds were tested for anti-inflammatory and antimicrobial activities. The anti-inflammatory activities were determined in the rat paw oedema induced by carrageenin. Compounds 6a, c, f and g (i.v.) significantly inhibited the rat paw oedema induced by carrageenin depending upon the dose employed. The compounds were also evaluated for their in vitro antimicrobial activity. Some compounds were found to have significant activity against Gram positive and Gram negative microorganisms. (C) 2000 Elsevier Science S.A. All rights reserved.
Subject: anti-inflammatory activity
potential antimicrobial agents
1,2,4-oxadiazoles
peptidomimetics
peptide synthesis
Country: Suíça
Editor: Elsevier Science Sa
Rights: fechado
Identifier DOI: 10.1016/S0014-827X(00)00099-9
Date Issue: 2000
Appears in Collections:Unicamp - Artigos e Outros Documentos

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