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Type: Artigo de periódico
Title: Synthesis of the C4-C17 Fragment of Saliniketals A and B
Author: Dias, LC
Perez, CC
Abstract: A highly stereoselective synthesis of the C4C17 fragment of saliniketals A and B was completed. The key steps in this synthesis included a syn-aldol reaction mediated by a boron enolate and a double diastereodifferentiating aldol reaction mediated by a titanium enolate. Moreover, a substrate-controlled Grignard reaction, an intramolecular Wacker-type cyclization and a SeyferthGilbert homologation provided the C4C17 fragment of saliniketals A and B in 16 steps and with a 7% overall yield.
Subject: Natural products
Asymmetric synthesis
Aldol reactions
Country: Alemanha
Editor: Wiley-v C H Verlag Gmbh
Citation: European Journal Of Organic Chemistry. Wiley-v C H Verlag Gmbh, n. 14, n. 2930, n. 2939, 2013.
Rights: fechado
Identifier DOI: 10.1002/ejoc.201300012
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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