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|Type:||Artigo de periódico|
|Title:||Structural characterization of two novel potential anticholinesterasic agents|
|Abstract:||Two novel compounds with possible anticholinesterase activity have been synthesized containing a carbamate and a dimethylamine group in 1,2-positions of a cyclohexane ring (cis and trans isomers). Conformer populations were established by a combination of NMR H-1 coupling constant analysis and DFT (B3LYP/6-311 + G(d,p)) calculations. C-13 chemical shifts were calculated in order to confirm signal attributions. The cis isomer adopts a conformation in which the carbamate group lies at the axial position (>99%), whereas the trans isomer adopts a diequatorial arrangement (98%). These preferences have been explained in terms of syn-1,3-diaxial interactions of the individual groups. (C) 2003 Elsevier B.V. All rights reserved.|
nuclear magnetic resonance
|Editor:||Elsevier Science Bv|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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