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Type: Artigo de periódico
Title: D,L-cis-2,3-pyrrolidine dicarboxylate alters [H-3]-L-glutamate binding and induces convulsions in mice
Author: Sinhorin, VDG
Carpes, MJS
Roehrs, C
Zimmer, MF
Sauzem, PD
Rubin, MA
Correia, CRD
Mello, CF
Abstract: This study investigated whether D,L-cis-2,3-Pyrrolidine dicarboxylate (D,L-cis-2,3-PDC), a new glutamate analogue, alters glutamate binding to cerebral plasma membranes and whether N-methyl-D-aspartate (NMDA) receptors are involved in the convulsant effect of this compound. D,L-cis-2,3-PDC reduced sodium-independent [H-3]-L-glutamate binding to lysed membrane preparations from adult rat cortex and had no effect on sodium-dependent glutamate binding. Intracerebroventricular administration Of D,L-cis-2,3-PDC (7.5-25 nmol/5 mul) induced generalized tonic-clonic convulsions in mice in a dose-dependent manner. The coadministration of MK-801 (7 nmol/2.5 mul), with D,L-cis-2,3-PDC (16.5 nmol/2.5 mul), fully protected the animals against D,L-cis-2,3-PDC-induced convulsions, while the coadministration of DNQX (10 nmol/2.5 mul) increased the latency to convulsions but did not alter the percentage of animals that had convulsions. These results suggest that D,L-cis-2,3-PDC-induced effects are mediated predominantly by NMDA receptors. (C) 2003 Elsevier Inc. All rights reserved.
Subject: binding
intracerebroventricular administration
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Pharmacology Biochemistry And Behavior. Pergamon-elsevier Science Ltd, v. 76, n. 2, n. 295, n. 299, 2003.
Rights: aberto
Identifier DOI: 10.1016/j.pbb.2003.08.012
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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