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Type: Artigo de periódico
Title: Targeted Disruption of Inducible Nitric Oxide Synthase Protects Against Aging, S-Nitrosation, and Insulin Resistance in Muscle of Male Mice
Author: Ropelle, ER
Pauli, JR
Cintra, DE
da Silva, AS
De Souza, CT
Guadagnini, D
Carvalho, BM
Caricilli, AM
Katashima, CK
Carvalho, MA
Hirabara, S
Curi, R
Velloso, LA
Saad, MJA
Carvalheira, JBC
Abstract: Accumulating evidence has demonstrated that S-nitrosation of proteins plays a critical role in several human diseases. Here, we explored the role of inducible nitric oxide synthase (iNOS) in the S-nitrosation of proteins involved in the early steps of the insulin-signaling pathway and insulin resistance in the skeletal muscle of aged mice. Aging increased iNOS expression and S-nitrosation of major proteins involved in insulin signaling, thereby reducing insulin sensitivity in skeletal muscle. Conversely, aged iNOS-null mice were protected from S-nitrosation-induced insulin resistance. Moreover, pharmacological treatment with an iNOS inhibitor and acute exercise reduced iNOS-induced S-nitrosation and increased insulin sensitivity in the muscle of aged animals. These findings indicate that the insulin resistance observed in aged mice is mainly mediated through the S-nitrosation of the insulin-signaling pathway. Diabetes 62:466-470, 2013
Country: EUA
Editor: Amer Diabetes Assoc
Citation: Diabetes. Amer Diabetes Assoc, v. 62, n. 2, n. 466, n. 470, 2013.
Rights: fechado
Identifier DOI: 10.2337/db12-0339
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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