Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/78974
Type: Artigo de periódico
Title: Systemic lupus erythematosus in patients with sickle cell disease
Author: Appenzeller, S
Fattori, A
Saad, ST
Costallat, LTL
Abstract: Sickle cell disease (SCD) is a prevalent genetic disorder that includes sickle cell anemia (hemoglobin SS), hemoglobin SC, and hemoglobin Sb-thalassemia. Patients with SCD present with a defective activation of the alternate pathway of the complement system that increases the risk of capsulate bacteria infection and failure to eliminate antigens, predisposing these patients to autoimmune diseases. The authors describe three patients with SCD that developed systemic lupus erythematosus (SLE). In all patients, SLE diagnosis was delayed because symptoms were initially attributable to SCD. Physicians should be alerted to the possible development of SLE in patients with SCD to not delay the diagnosis and start appropriate treatment.
Subject: sickle cell disease
systemic lupus erythematosus
Country: EUA
Editor: Springer
Rights: fechado
Identifier DOI: 10.1007/s10067-007-0779-7
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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