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Type: Artigo de periódico
Title: Systemic inflammation caused by chronic periodontite in patients victims of acute ischemic heart attack
Author: de Oliveira, FJ
Vieira, RW
Coelho, OR
Petrucci, O
de Oliveira, PPM
Antunes, N
de Oliveira, IPF
Antunes, E
Abstract: Objective: Infectious and inflammatory processes mediated by bacteria in distant sites have been described as a risk factor for acute ischemic heart disease (AIHD). Methods: One hundred one patients with AIHD with and without chronic periodontitis (CP) were included in this study. Patients were admitted to the HC UNICAMP and stratified into three groups: in group 1, we selected patients with severe chronic periodontitis (31 men and 19 women, mean age 55.1 +/- 11.29 years old); the group 2 with mild chronic periodontitis (40 men and 28 women, mean age 54.8 +/- 10.37 years old) and group 3 represented by the toothless (43 men and 20 women, mean age 67.5 +/- 8.55 years old). Blood samples were collected to measure the lipid profiles, hematological and blood glucose levels. In addition, biopsies of seventeen coronary arteries with atherosclerosis and an equal number of internal mammary arteries without atherosclerotic degeneration in group 1 were investigated. Statistical analysis by analysis of variance (ANOVA) and Scheffe test for multiple comparisons was performed. Results: Triglyceride and LDL levels were elevated in group 1 than in group 2. HDL were reduced by 20% in group 1 and remained reduced by 8% in toothless. Blood glucose was higher in group 1. DNA of periodontal bacteria was detected in 58.8% of the coronary arteries. Conclusions: Patients with (AIHD) and severe chronic periodontitis may have altered lipid profile, as well as microorganisms associated with CP can permeate into coronary vessels.
Subject: Periodontitis
DNA, bacterial
Risk factors
Coronary disease
Country: Brasil
Editor: Soc Brasil Cirurgia Cardiovasc
Rights: aberto
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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