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Type: Artigo de periódico
Title: Synthetic studies directed toward the total synthesis of dolabriferol
Author: Dias, LC
de Sousa, MA
Abstract: Herein we report our results towards the total synthesis of (-)-dolabriferol, describing the synthesis of fragments C1-C9 and C10-C21. This convergent asymmetric approach relies on the use of a common Weinreb amide precursor for the preparation of both fragments, an efficient anti-aldol reaction followed by Zn(BH4)(2) reduction to give a 1,3-syn diol, a selective oxidation of a triol under Swern conditions with concomitant lactol formation, and a diastereoselective epoxidation of an allylic alcohol with m-CPBA followed by an efficient epoxide opening with Me2CuCNLi2. (C) 2003 Elsevier Ltd. All rights reserved.
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Tetrahedron Letters. Pergamon-elsevier Science Ltd, v. 44, n. 30, n. 5625, n. 5628, 2003.
Rights: fechado
Identifier DOI: 10.1016/S0040-4039(03)01351-0
Date Issue: 2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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