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Type: Artigo de periódico
Abstract: Treatment of mice with staphylococcal enterotoxin B (SEB) induces specific T-cell tolerance to this superantigen, characterized by partial deletion of V beta 8(+) T cells in vivo and T cell anergy in vitro. In this study we examined the humoral response to SEB in BALB/c mice. Immunization of mice with SEB results in a detectable anti-SEB antibody response. Upon further treatment of mice with SEB, specific antibody levels increase significantly and the response is accelerated-characteristics of a secondary humoral response. The secondary antibody response is T cell dependent, can be transferred to T cell deficient mice with splenocytes and is composed mainly of IgM, IgGI and IgG2b isotypes, suggesting that Th2 cells provide B cell help in this response. These data demonstrate that at the same time as inducing in vitro unresponsiveness, SEB primes SEB-specific T helper cells to provide help for B cells in a secondary antibody response.
Country: Inglaterra
Editor: Blackwell Science Ltd
Citation: Scandinavian Journal Of Immunology. Blackwell Science Ltd, v. 42, n. 3, n. 305, n. 310, 1995.
Rights: fechado
Identifier DOI: 10.1111/j.1365-3083.1995.tb03660.x
Date Issue: 1995
Appears in Collections:Unicamp - Artigos e Outros Documentos

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