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|Type:||Artigo de periódico|
|Title:||T-CELL-DEPENDENT ANTIBODY-RESPONSE TO STAPHYLOCOCCAL-ENTEROTOXIN-B|
|Abstract:||Treatment of mice with staphylococcal enterotoxin B (SEB) induces specific T-cell tolerance to this superantigen, characterized by partial deletion of V beta 8(+) T cells in vivo and T cell anergy in vitro. In this study we examined the humoral response to SEB in BALB/c mice. Immunization of mice with SEB results in a detectable anti-SEB antibody response. Upon further treatment of mice with SEB, specific antibody levels increase significantly and the response is accelerated-characteristics of a secondary humoral response. The secondary antibody response is T cell dependent, can be transferred to T cell deficient mice with splenocytes and is composed mainly of IgM, IgGI and IgG2b isotypes, suggesting that Th2 cells provide B cell help in this response. These data demonstrate that at the same time as inducing in vitro unresponsiveness, SEB primes SEB-specific T helper cells to provide help for B cells in a secondary antibody response.|
|Editor:||Blackwell Science Ltd|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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